Pathogenesis of vitiligo
نویسندگان
چکیده
منابع مشابه
The pathogenesis of vitiligo.
BACKGROUND Vitiligo is a commonly encountered pigmentary disorder. Numerous studies and investigations from all over the world have attempted to determine the mechanisms behind this disease; however, the pathogenesis of vitiligo remains elusive. OBJECTIVE n this comprehensive review article, we present the findings behind the five overarching theories of what causes this disfiguring and psych...
متن کاملNeuro-immuno-endocrine processes in vitiligo pathogenesis.
Vitiligo is a cutaneous disorder of depigmentation, clinically characterized by well-demarcated, white macules of varying size and distribution. It can affect up to 2 percent of the population, especially younger ages. In spite of recent findings implicating genetic, immune and oxidative stress factors, the exact pathogenesis of vitiligo remains obscure. Here, we briefly...
متن کاملRegulatory T cells in vitiligo: Implications for pathogenesis and therapeutics.
Vitiligo is a hypomelanotic autoimmune skin disease arising from a breakdown in immunological self-tolerance, which leads to aberrant immune responses against melanocytes. Regulatory T cells (Tregs) are crucial to the development of self-tolerance and so are major foci in the study of autoimmune pathogenesis of vitiligo. This review will summarise recent findings concerning the role of Tregs in...
متن کاملThe Haptogenic Pathogenesis of Vitiligo and the Source of the Pattern of Depigmentation
The pathogenesis of vitiligo based on the model of depigmentation produced by topical application of phenolic compounds that are substrates for tyrosinase is outlined. The main steps in the pathway consist of the haptenation of melanosomal proteins by the quinone products of the analogue phenols with the generation of neo-antigens which are able to elicit a cell-mediated immune response that re...
متن کاملSystematic understanding the mechanisms of vitiligo pathogenesis and its treatment by Qubaibabuqi formula.
ETHNOPHARMACOLOGICAL RELEVANCE Vitiligo is a depigmentation disorder, which results in substantial cosmetic disfigurement and poses a detriment to patients' physical as well as mental. Now the molecular pathogenesis of vitiligo still remains unclear, which leads to a daunting challenge for vitiligo therapy in modern medicine. Herbal medicines, characterized by multi-compound and multi-target, h...
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ژورنال
عنوان ژورنال: Journal of the Korean Medical Association
سال: 2020
ISSN: 1975-8456,2093-5951
DOI: 10.5124/jkma.2020.63.12.725